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PAT for inline particle size analysis
PAT for inline particle size detecting granulation end point of fluid bed and high shear granulation, controlling micronization, milling, spray drying and facilitating real time monitoring and release.
The particle size distribution of a pharmaceutical is recognized as one of the most critical physical parameters for consistent therapeutic performance.
Malvern’s PAT particle size analyzer range enables inline particle size characterization of granules, particles and droplets in processes such as fluid bed granulation and coating, high shear granulation, dry and wet milling and others.
Adoption of Process Analytical Technology can help:
- Trend and detect end point of fluid bed and high shear granulation or coating processes
- Control quality in milling and micronization processes
- Implement adaptive process control techniques
- Streamline product and process design
- Facilitate continuous manufacturing via real time monitoring and release
- Reduce operator exposure to high potency substances
- Lighten the workload of a QC laboratory.
Malvern solutions for PAT
Inform - Pharmaceutical manufacturing: The challenge of setting effective product specifications
Setting meaningful and realistic specifications is an essential element of Quality by Design (QbD). Well-defined specifications control product performance...
Implementing PAT and QbD - Real-time particle size measurement for the pharmaceutical industry
As the pharmaceutical industry implements PAT and QbD, their symbiotic nature becomes increasingly obvious. Both are catalysts towards the longer term goals of continuous...
The importance of on-line particle size analysis for the pharmaceutical industry
The pharmaceutical industry recognizes that a paradigm shift in processing approach is required and the PAT initiative reflects this....
Aspects of particle sizing in pharmaceutical manufacturing
Anyone engaged in the development, formulation or manufacture of pharmaceuticals is likely to have some understanding of the role of particle size in determining the...
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